The second group of Amazing Race contestants set out on a race around the world for one hundred thousand dollars. The ten teams left the Asian Civilisations Museum near the Singapore river where they faced gruelling challenges such as a high physical task in a Detour. Teams then made their way to Manila in the Philippines where teams were required to use GPS systems to guide their Taxi drivers to the next location. Later, at the Plaza Miranda, teams had to eat eight baluts from an egg-seller's store before receiving their next clue from the egg seller. Teams then made their way to the Pit Stop located at Fort Santiago. Two teams raced each other to reach the mat first as another team was too late to catch up and stepped onto the mat last. They were relieved to know that had not been eliminated but were instead given a penalty.

All of the ten remaining teams continued racing in the Philippines where they eventually encountered their first Roadblock. To complete the task, one member had to get down and dirty by leading a carabao around a muddy field through a marked course. Teams then made their way back to Manila where they had to complete an additional task of loading and delivering food. Later, teams faced a Detour in which teams were given the choices of "Heel" or "Wheel". "Heel" required careful matching while "Wheel" is more of a puzzle task of assembling a bicycle. Lastly, teams had to make their way to Paco Park and Cemetery, the Pit Stop for this leg of the race. The clue stated that this was an elimination round so teams tried to gain higher positions as much as they could. Ultimately, a true photo finish resulted in the elimination of one team.

The nine teams continued on to Hong Kong before heading directly to New Zealand where teams faced a Roadblock involving a bungee jump off the Auckland Harbour Bridge. Teams also experienced Rock climbing or a wet and wild task in a tiresome Detour. After a close foot race, one team was unable to catch up and were the last to arrive at the Pit Stop. This lead to their elimination.

Eight teams leave Auckland and continued their adventures in New Zealand as they drove to Rotorua. At the Okere Falls Scenic Reserve, teams experienced white water sledging followed by riding on a Agrojet craft through Blue Lake. A Roadblock forced team members to search the hot mud baths of Hell's Gate for their next clue. For the Detour at a Maori village in Te Puia, teams must choose between Flax (weaving a traditional Maori headband) and Sticks (tossing training sticks to the beat of drum music). One team failed to recover after starting the leg nearly six hours behind and was eliminated.

In this leg's first Detour, teams had to choose between You Catch It or You Cart It. In You Catch It, teams had to participate in the traditional game of goldfish scooping, using paddles made of rice paper (which disintegrates very easily when immersed in water) to scoop up 40 goldfish with paddles. In You Cart It, teams had to locate a dry cleaner's store and collect a yukata which they had to deliver to a certain address. In the first Roadblock, one team member had to decipher an ice block puzzle. The answer would be the name of one of the biggest cities in Japan. Once the team member has figured out the answer, the personnel will hand them their next clue. In the leg's second Detour, teams had to choose between Slither or Deliver. In Slither, teams had to proceed to the Jagalchi Fish Market where they will have to find a marked fish tank filled with octopus. Each team member must retrieve one 100-year old Korean coin (token) from the bottom of the tank before receiving their next clue. In Deliver, teams had to deliver six meals to three different addresses, some of the deliveries in which might have an ambiguous location. In the second Roadblock, teams proceeded to Yongdusan Park and look for a gatekeeper. The team member must then use the key given to search and open one of the locks before the gatekeeper will hand them their next clue. Teams will have to start over if they break their key.

In this Roadblock, one team member had to search under the lids of 1,500 soybean jars until they find one which contains their next clue. One of the jars will contain the clue plus a US$50 bonus from Standard Chartered, which Adrian and Collin won. In this Detour, teams had to choose between Too Ho and Too Heavy. In Too Ho, teams had to play a traditional Korean game where they have to throw three bamboo stickets into a cylinder 4.5 metres (15 ft) away. In Too Heavy, teams had to deliver 30 logs in a traditional carrying device and deliver it to a woman somewhere inside the village before receiving their next clue.

In this Roadblock, one team member had to don a full suit of knight armour and then walk around to look for a "damsel in distress", who is standing on a balcony facing the Prince's Hotel. Once teams find her, they have to tie the key to a rope which the "damsel" would exchange for their next clue. In this Detour, located in Nižbor (Czech), teams had to choose between Bow or Blow. In Bow, each team member had to hit a coloured red-and-yellow target using a traditional crossbow. In Blow, teams had to travel to Rückl Crystal and use mechanical tools to cut a star-design on a number of glass bottoms

In this Detour, intersected teams had to choose between Snap or Roll. In Snap, teams had to take photos of three historic monuments (Statue of St. Wenceslas in Wenceslas Square, Lenin Statue in Museum of Communism, and Estates Theatre) in Prague and submit the photographs as evidence before the personnel positioned in front of the Statue of Josef Mánes would hand them their next clue. In Roll, teams had to locate Hostinec U Váhy and collect two 50-litre (13 gallons) beer kegs and roll it to the Admiral Botel. After the Detour, they are no longer intersected. In this Roadblock, one team member had to climb up to a ten-meter high diving board and jump off it into the pool below to receive their next clue.

In this Detour, teams had to choose between Pitch or Pull. In Pitch, teams had to load a large pile of hay into a donkey cart and then go for a ride as a local drives the cart to a nearby farm. In Pull, teams had to milk a goat and obtain 200ml (7 oz) of milk. Then, they had to place the goat in a pen and secure it before receiving their next clue. In this Roadblock, one team member had to experience several legs of flying fox obstacles while adding up several numbers found around the course which would add up to 1,000. Team members that do not get the correct number will have to restart the task and if there are other teams present, will be sent to the back of the line and have to wait their turn till the other teams in front of them are done or have to restart as well.

In this Fast Forward, teams had to count the number of fence posts on Erzsébet Bridge and then with the number obtained, use it to open a safe with the 4-digit figure of fence posts (the correct digit was 2-3-7-7). The first team to open the safe won the Fast Forward award. In this Roadblock, one team member had to take a lantern and search through the dark and confusing labyrinth of tunnels in Buda Castle to search for several chests. However, only one of these contained the team's next clue. In this Detour, teams had to choose between Say It or Play It. In Say It, teams had to correctly pronounce (in full local accent) the names of 14 prominent Hungarian rulers, a potential tongue twister. In Play It, teams had to solve a Rubik's Cube (a Hungarian invention) but were given the option to solve one side by one side (to get the same colour on each side) for all six sides, alternating between team members.

In this Roadblock, one team member must race eight laps around the Killarney racing circuit on a 450 horsepower (340 kW) open-wheel race car. After four laps, they must enter the pit area for a mandatory tune-up. If the team members entered it within seven minutes he/she could immediately exit and complete the task; otherwise, a five-minute time penalty would be incurred. In this Detour, teams had to choose between In One End or Out The Other. For In One End, teams must prepare 100 kg (220 lbs) of food and feed them to the elephants. Only after the elephants finish the entire meal could teams collect their next clue. In Out The Other, teams must clear the elephant stalls of dung onto a marked area, using only the tools provided.

In the final Detour, teams travelled to Victoria & Alfred Waterfront and had to choose between Search or Assemble (This option was presented as "Sound" in the teams' clue). In Search, teams had to go The Scratch Patch and search amongst thousands of semi-precious gemstones for the three race stones which were yellow in colour and marked with a red dot. They will trade these three stones for their next clue. In Assemble, teams had to go to Waterfront Craft Market and watch a demonstration on how to assemble a wire-frame radio. Once teams had successfully put together a working radio using the tools provided, they would receive their next clue. In this Roadblock, one team member had to grab flags from the ten different countries they visited on the Race and arrange them in the order that they visited them. Once teams got the correct order of correct flags, they may retrieve the final clue.

The final race to the finish line.