Gelai may not have been lucky to have a complete family, but she has her real mother Gigi and aunts Linda and Rose to show her utmost love and care. As years passed by, she grew closer to her aunts while her mom lived away from them because of work. With three people looking after her, Gelai still believed their love was not enough. In high school, she learned to cut classes, go home late, and neglect her studies. The situation even got worse when she had a boyfriend who taught her different kinds of vices. How did her three mothers handle her situation? Did she find the missing piece in her life that she was looking for?

Ever since she was a child, Joy has always been a Daddy’s girl. She grew up getting even closer to her dad, Rolando, because of their common love for running. Every race she joined in, Joy would always find her father waiting for her at the finish line. Running didn’t only serve as a bonding activity for her and her dad, but it also enabled her to finish her studies via an athletic scholarship. Everything in her life was moving at a steady pace until one day, she received the unfortunate news that her father is suffering from pneumonia just moments away from competing in a national marathon. Did she continue the race or did she opt to see her father?

At a young age, Paolo vowed to help his blind mother, Tess (Irma Adlawan), in raising their family. This motivated him to study hard and finish college, and immediately landed a job as a customer sales representative in Manila. Paolo became unstoppable and steadily climbed up the corporate ladder, until his eyes started to blur. Because of his condition, his colleagues discriminated and made fun of him. Depressed by the criticisms, he chose to leave his work and return to Baguio to his family. How did Paolo rise above the situation? What pushed him to become a motivational speaker in his community?

Before he rose to prominence as a pioneering neo-realist painter, Cesar had been stricken with several diseases, but was cheered on and taken care of by the love of his life. A sickly mestizo boy, Cesar was studying fine arts in college when he found out that he was color blind - a disability that shattered him but did not deter him from pursuing his dreams to become an artist. In the 1930s, he met the woman who would become his life's greatest supporter, Betty, but together they would brave challenges in order for their love to flourish. A mestizo with Spanish roots, Cesar was not immediately accepted by the family of Betty, whose grandfather was a Katipunero. Betty's family eventually agreed to the young lovers' marriage, which would become tumultuous as Cesar got sick with emphysema and became bedridden. He eventually worked at a promotions company making art for advertisements, putting his own art on hold to provide for his family.

Among the siblings, twins Bea and Nina were closest to their father, Robert They looked up to him so much and really saw him as is a reliable and an ideal father. One day, Robert went missing and the kids were made to believe that he was sick. Years passed and there was still no sign of him. In his absence, mother Evy took on the roles of both being a mother and a father. When Robert finally came home, things went back to normal. But that was until Bea and Nina discovered that he is drug addict. How did they accept their father's state? How did they help him change for the better?

Magic has always had a special place in Rosela's heart since it is what binds her to her father, Ruperto. However, after Ruperto unexpectedly dies, their family struggles financially, forcing Rosela and her siblings to start working. She promises to honor him by still making him proud one day. Rosela finds a way to continue her education, but eventually returns to her true passion against the wishes of her mother, Josie, who believes magic is a waste of time. Will Rosela fulfill her promise to her father by achieving her dream of becoming a magician, or by abandoning her passion to provide for their family?

Alma is forced to become an OFW because of her family's poverty. Despite her husband, Manuel's, protests she leaves home to go work in Dubai, where she is mistreated and abused, and even raped by her employer. She will hide what she went through from Manuel and their children. Instead of a good life for her family, she will come home ashamed and bearing a secret - she is pregnant as a result of the tragedy she experienced.Will Alma's family ever learn to accept what happened to her and the child that came of it?

Ever since he was young, Jarel has always been determined to finish his studies and help lift his family out of poverty. He drew inspiration from his mother Fe, who worked as a maid to send her siblings to school, which is why he also became a house helper. However, Fe is against his decision as she does not want him to endure the hardships and judgment she faced while working as a maid. Despite her protests, Jarel will persevere with his choice as he believes it is the only means for him to achieve his dream. Will Jarel be able to show that being a kasambahay is not the end of achieving his dreams or will he prove Fe right that it will only bring him hardship and make others judge him?

Charo is a marine life researcher, who travelled to different places in the Philippines. She meets an old man in Tawi-Tawi who gives her an amulet that she soon believes gives her protection. She puts her faith on the amulet, which ironically led to a series of misfortunate events in her life. She lost her job, mourned for the death of her father, and acquired hypothyroidism. Consequently, she loses herself and begins to hear voices. Charo then makes the ultimate decision to burn her most prized amulet when a friend advised her to throw it away. Charo's condition worsens and she is slowly engulfed in a world of unknown voices that only she can hear. She only finds solace in making songs out of the voices she hears in her head which her elder sister, Manay Jean is against, thinking it will only worsen Charo's condition. Will Bela be left alone by the amulet and the voices she hears? Will Manay Jean be able to come to terms with the song compositions from the unknown voices only her sist

Christian and his family lead a comfortable life because of their persevering parents Racquel and Robert. Unfortunately, both husband and wife will get hooked on gambling, eventually causing problems for their family and putting a strain on their marriage that will almost lead to their separation. When Racquel gets sick to the point of seeming like being possessed, Christian strives to keep his family together. This doesn't get easier with the additional financial and personal problems they have to face together as a family, and their parents won't be able to take care of them. Will Christian's family ever be complete again? How will he stop his mother from leaving their family when her case worsens?

Since childhood, Sarah had premonitions that allowed her to foresee tragedies-including events that have shaken the world. Sarah eventually marries Michael, a loving and patient husband who will care for her despite the challenges to Sarah's physical and spiritual well-being-including her blindness, abnormal vaginal bleeding, and the continuous dark visions she encounters. One day, Sarah is advised by a friend to consult a priest in the Archdiocese of Manila. There, the priest points out that the cause of her unexplainable health situation and visions were dark forces - or what is called "demonic oppression" a lesser form of "demonic possession." The priest also attributes Sarah's situation to her unvented anger towards her parents. Will Sarah ever find peace in her life? Will she be able to fully reconcile with her parents?

The "bread winner" of her family, Sheila has always put her loved ones' needs first. Because of this, it takes a while before she gets into a relationship. She meets the seaman Rey who pursues her. She tries to deflect him because of Rey's reputation as a womanizer. But as fate would have it, they fall for each other and are blessed with a daughter, whom they name Lyka. One day, Sheila discovers that Lyka has HIV, which they traced back to Rey brought about by him sleeping around before they got married. What's even worse is she has contracted HIV herself. Rey's health eventually deteriorates and he dies leaving Sheila to raise Lyka all by herself. She tends to her needs as well as her daughter's in every way possible despite her own condition. Sheila hides the truth from Lyka who she brings up as a normal child for fear of judgement from society. Lyka grows up loved and cared for and will only know the truth after her mother discloses the truth when her first period came.