Two years after student Natalee Holloway disappeared while on vacation in Aruba, the team looks for new clues to what really happened.

The team investigates four murders that took place over a seven-year period in League City, Texas, in which the young female victims all ended up buried in the same field.

The team investigates the death of a Native American teenager from Montana whose body was discovered along a highway in North Dakota.

The team investigates the strange disappearance of Massachusetts man James Lacouture in 1988 after a night of heavy drinking, and his older brother David's apparent suicide a few days later.

After a Saturday night out with friends, 28-year-old Joyce Chiang stopped at a Starbucks in DuPont Circle before walking home. That was the last that anyone saw of her. Months later, Chiang's lifeless body is recovered 10 miles downriver from Washington D.C. Despite all the media attention, the case soon went cold. Two years later, 24-year-old Chandra Levy also disappeared. Like Joyce, Chandra was a petite brunette who lived in DuPont Circle and frequented the same Starbucks. Curiously, both women interned for congressmen and both of their bodies were abandoned in D.C. parks. Does the team believe a serial killer is still prowling DuPont Circle?

The team investigates the 1998 disappearance of a North Carolina teen shortly after moving to the San Francisco area to take art classes.

Psychic detectives investigate the unsolved disappearance and subsequent murder of Judith Smith

Investigating the murders of two girls who were last seen alive getting into a blue truck at a convenience store in Arizona.

The grisly murders of two girls in 1999 continue to haunt Dothan, Ala.

The team goes to Villisca, Iowa, to investigate the 1912 massacre in their beds of two adults and six children by an unknown killer with an ax.

John, Carla and Patrick go to Ohio to search for clues in the disappearance of a 25-year-old man.

A construction worker in Kansas falsely claims he needs to report for jury duty, leaves his job early and is never seen alive again.