Chiropractor Dr. Colón treats Liana, a cane-bound woman suffering from involuntary tremors. Sarah's obsession with corsets causes her migraines. Amy, a little person, can no longer walk on her own. Dr. Colón sees Brenda, an uncontrollable farter.

Dr. Colón helps a woman who cannot keep her joints in place; a new mother suffers from a tragic boat accident; a bodybuilding leukaemia survivor; a constipated baby.

Dr. Colón faces more chiropractic challenges when she treats a woman with CMT who hopes to stand at her daughter's wedding, a big breasted woman with extreme neck pain, and the show's sound man, who was born with cerebral palsy and an uneven body.