Davina McCall and Nicky Campbell return to tell incredible stories of people desperate to find missing family and answer questions that have haunted entire lives. This week features two stories of children searching for their birth mothers after life-changing events - former Scotland footballer Dominic Matteo, who started to search after suffering a life-threatening brain tumour, and a woman, pained with emotion on her wedding day because her birth mother was missing.

Davina McCall and Nicky Campbell present the stories of two people trying to unravel family mysteries, with both looking for a birth parent they have never met. Fifty-seven-year-old quarry worker John Hacking was told that his birth mother left him as a baby in a pram outside a block of flats in Buxton and has been searching for her since he was 17 with no luck, while Debra Spark has never met her Italian father Ernesto, who got together with Debra's mother Olive in Milan in the 1960s.

Davina McCall and Nicky Campbell present the stories of two women trying to find birth parents after half a century apart. Ann Melbourne found her birth mother over a decade ago and now wants to locate her birth father Leslie, who she has limited information about in her adoption paperwork, while Amanda Village is searching for her mother Susan, who gave her up for adoption.

This week, Paula Stillie is on a quest to discover her identity, and Lisa Harding longs for the sister she's always wanted. Paula Stillie has always looked completely different from her white adoptive family in Scotland. Heartbreakingly, as a little girl she covered herself in talcum powder to try and look more like her parents. Although she had a happy upbringing, she's always wanted to know who her birth family are and where in the world she comes from. Our search for answers leads across the globe with some unexpected surprises. Meanwhile, Lisa Harding grew up in the north east of England with her single mother Moyra who worked long hours as a hairdresser by day and taxi driver by night. It was a lonely childhood and Lisa always wished for a sister. Then when Lisa was 15, Moyra confided that Lisa actually has an older sister who was given up for adoption before Lisa was born. But the decades went by, and because the subject was painful, they didn't speak about it again, until Moyra was dying of cancer and she told Lisa of her desire to find her eldest daughter. Now Lisa is on a mission to fulfil her mother's dying wish.

An extraordinary search on behalf of Kate Brown from Portsmouth takes on twists and turns and unveils one missing relative after another. Kate Brown with a foster family and the closest thing she had to a blood relative was her foster brother John, who she was very close to, but while Kate was eventually adopted by the foster family, John was sent back to the care system. Ever since, Kate has been on a mission to find him, and during her research, she made an unexpected discovery.

Davina McCall and Nicky Campbell present two heartbreaking stories of separation, including a man whose only memento of his birth mother and siblings is an old local newspaper article that shows them evicted from their home and squatting in an airfield. Plus, a woman searching for her only child, who she hasn't seen since he was 10 days old.

Davina McCall and Nicky Campbell present the stories of people searching for siblings. Steve Austin and Moira Tonge only found each other as adults, but then at their mother's funeral discovered they also had an older sister. Lisa Irvine also only found out about her brother Nicholas as an adult, when she read her adoption paperwork and wants to know what happened to him and her birth mother.

Davina McCall and Nicky Campbell present two more stories, with Louise Stoppani looking for the father she never knew, having discovered aged seven that the man bringing her up was not her biological dad. Jonathan Gaskarth was adopted at six weeks old, but it was only following the breakdown of his marriage that he decided to try to locate his birth parents.

With his 87th birthday approaching, retired merchant seamen Roy David searches for his daughter Cheryl, who he has not seen for nearly 60 years. After meeting his first wife Sylvia in New York while working there, the couple had a daughter, but tensions within the family lead to him separating from his wife, and eventually losing touch. Now, Roy seeks forgiveness from Cheryl and hopes to make amends.