UFC Primetime

The event was expected to be headlined by a UFC Light Heavyweight Championship bout between then champion Jon Jones and top contender Anthony Johnson. However on April 28, following Jones' hit-and-run incident, the UFC decided to strip him of the title and suspend him indefinitely. He was replaced by the previous title challenger Daniel Cormier, who was scheduled to face Ryan Bader in the main event of UFC Fight Night 68. The co-main event featured a UFC Middleweight Championship bout between current champion Chris Weidman and former UFC Light Heavyweight champion and UFC 12 Heavyweight Tournament winner Vitor Belfort. The much delayed pairing had been rescheduled for several events. The first of which was UFC 173, where Belfort withdrew from the bout following the Nevada State Athletic Commission's ban on testosterone replacement therapy. The other events were UFC 181 and UFC 184, where Weidman withdrew from both bouts because of a broken hand and injured ribs, respectively.

The event was headlined by a UFC Heavyweight Championship unification bout between then champion Cain Velasquez and then interim champion Fabrício Werdum. The bout was originally expected to take place at UFC 180. However, Velasquez pulled out of the bout due to a knee injury and the event was instead headlined by an interim title bout between Werdum and Mark Hunt. A lightweight bout between Francisco Trevino and Johnny Case was originally expected to take place at UFC Fight Night: McGregor vs. Siver.[6] However, on December 23, it was announced that Trevino had to pull out of the bout due to an injury. The fight was later rescheduled for this event.