They attempt to help a terminally ill photographer who can no longer use his hands to operate a camera. They try to bring cutting-edge communication to a remote Welsh village which has no internet access and an unreliable telephone connection. And they work to give some control back to a young designer who has Parkinson's disease and who has been unable to use a pen since developing tremors in her hands two years ago.

The team attempt to tackle one of the biggest rural crimes in the UK and work to find a way to build a BMX bicycle for a young boy who was born with no hands or feet. Meanwhile, in Peterborough, 56-year-old Graham is suffering from locked-in syndrome, meaning he is almost completely paralysed and unable to speak. Can the team come up with a way for him to have conversations with the medical team around him and, most importantly, his family and friends?

Mum of two Shamreen suffers from a degenerative condition which has left her with very limited vision, and she is struggling to get around in public with her two young sons. Seven-year-old Rosie had brain surgery as a baby and now wears a cumbersome medical helmet. She desperately wants the team to invent her a new helmet that will be less visible and help her fit in with her friends. And the team are challenged with coming up with a solution to help two teenage brothers with cystic fibrosis - a debilitating disease that severely affects their breathing.