New residents arrive including Steven Adler, Jeff Conaway, Rodney King, Tawny Kitaen, Nikki McKibblin, Amber Smith and Sean Stewart, along with Gary Busey as a mentor for the group.

Although the patients have just entered the rehab there are already rumblings. Gary Busey doesn't like that he's been placed in with the patients instead of a source of inspiration in which he believed he had signed up for. Dr. Drew sets him up a psychological exam and an amazing discovery is revealed. Jeff and Vikki can't seem to stay away from each other as ordered. Nikki, Jeff and Amber seem to be having the toughest time in the detoxifying portion of the program. Steven had recently detoxed at a hospital and is having nightmares as he starts coming out of the fog. Rodney uses exercise to help clear away his demons. Tawny is having trouble sleeping since her meds have been taken away. But family and friends are finally let in for the day to help ease their pains, except for Jeff who is having troubles again with Vikki. As the guests leave Gary gets out of hand and nearly shoves Steven's wife out the door and gives "secret" conversations to Tawny and Amber, shoving the cameraman when he realizes the talks were being filmed.

Day 4 of rehab finds the patients emerging from their painful withdrawal sickness, and Dr. Drew begins exploring what made the addicts misuse drugs and alcohol in the first place.

Dr. Drew begins chatting with the celebs about their mothers and how they relate to their addictions, which proves to be a touchy subject for some. Also, Jeff's back pain is getting the best of him and he reveals his fear of being around his girlfriend because of what she may do to him. Dr. Drew will confront Vikki on what Jeff has explained and try to find a constructive resolution to their domestic issues. later, Dr. Drew connects some patient's drug addiction with sexual and physical abuse. Jeff finds himself unwilling to accept any form of healing his back other than another surgery and resorts to calling the police to say he is being held captive.

After calling 911, Jeff decides to continue rehab with Dr. Drew. The group attends art therapy and Gary and Jeff have a very heated argument. Later, an emergency meeting is called to deal with Gary's issues.

Family weekend has arrived for the group and everyone is worried about how their family will react to the rehab process. Rodney reaches a breakthrough with his daughters and later the patients and their families enjoy a day at the beach.

It's day 15 in the rebab facility and Dr. Drew arranges for some of the patients to do volunteer work at a homeless mission. As therapy continues, Jeff worries about what he will do with his life once outside of rehab. Later, Dr. Drew is called by season one participant, Seth "Shifty" Binzer's sponsor and is brought in to coach "Shifty" out of a crack binge.

It's day 18 in rehab and Shifty from season one has had a relapse and has returned to rehab. A discussion about sober living progresses, Steven has a violent outburst. Dr. Drew reveals that he wants all of the patients to live at a sober house after rehab is over. Later, the group heads out to a comedy club to get their mind off of rehab.

Graduation is near, but Jeff will not be a part of it. After kicking his girlfriend, Vikki, in the chest, she forgives him and Jeff is told he has to leave rehab. The rest of the group discuss sober living and their decisions after graduation.