Larry David, Lisa Lampanelli, Jay Sean, Birdman

Andy Garcia, Real Housewives of OC, Justin Bieber

Sandra Bullock, Derek Luke, Shakira

Taye Diggs, Kaley Kuoko, Ruben Paul

Laurence Fishburne , Olivia Munn, Los Lobos

Kathy Griffin, Rico Rodriguez

Cedric the Entertainer, Corona Girl & Morrissey

Hilary Duff, Scott Bakula & Rudy Moreno

Mark Harmon, 50 Cent

After George's opening standup, which was G-rated due to all the kids in the crowd, "Creepy Little Sitcom Mom" (Belita Moreno) paid a visit to deliver bad news about George's old haircuts, among other things. Belita then joined George on the stage to reminisce about their work together on the show. She also admitted to stealing a few mementos from the set. Constance Marie joined them and talked about the early days of the sitcom, when George was a novice actor... and how George's real-life wife cast her as George's sitcom wife! Then, Valente Rodriguez joined the party -- the guy who can make George laugh like no one else can. George welcomed the kids from the show -- Luis Armand Garcia, Masiela Lusha and Aimee Garcia. They thanked George for the experience of working on "George Lopez" and talked about how their lives have changed since then. George got teary-eyed as he shared his thoughts on what the show means to him. Then came the "George Lopez" finale they never got to make, which included a cameo by Leah Remini.

David Beckham & Mariah Carey

Ray Romano, Lake Bell & "Jersey Shore"

Charles Barkley

Amber Valletta, Mark Valley

Brendan Fraser, Khloe and Kourtney Kardashian

Tyrese Gibson, Betty White

Samuel L, Jackson, Dianna Agron

Cheech and Chong, Regina King

Sofía Vergara, James Van Der Beek

Chris Jericho, David Arquette, Elizabeth Chavira,Trey Songz

Eric Andre, Eva Longoria, Sinbad

John Corbett, Mark Littell, Nicole Scherzinger, Steve Lyons

Brandy, Ray J

Bruno Tonioli, George Wallace, Taraji P. Henson

Slash, Zachary Levi

Chris Rock, Oscar De La Hoya, Sugar Shane Mosley

Luke Wilson, Monica

Kara Dioguardi, Cheech Marin & Tommy Chong, Jason Reeves

Angela Kinsey, Brendan Fraser, Jason Aldean

Chris Evans, Idris Elba, Lowell Sanders, Zoe Saldana

Jennifer Lopez, Ken Jeong, Ozomatli

Lopez Tonight celebrates its 100th episode, with guests Kobe Bryant and Louis C.K. with special appearances from Arsenio Hall, Clint Eastwood, Tom Cruise, Donald Trump, Russell Brand, and Eddie Van Halen. At the end of the show, George alongside his band performed the Van Halen song "Panama".