Luna, the new resident at the Emergency Department, is doing her best to prove herself. It doesn't help that her mother Rose is on her skin. Chief physician Milo skillfully keeps his affair with nurse Ingrid hidden. The highly flammable nurse Kees has to deal with difficult patients. Rose, an oncologist and board member, fights against budget cuts and impresses the new psychiatrist Casper in doing so.

Luna does not follow protocol when she administers morphine to a patient and gets her mother on her roof. Milo and Casper get stuck in the treatment of a critically ill man with fear of needlesticks.

Luna sympathizes enormously with a seriously ill patient and therefore speaks loudly. Rose doubts whether Luna is tough enough for her profession. Rose herself is under pressure to make cuts.

Luna comes into conflict with the more experienced nurse Kyra about a pregnant patient who is considering an abortion. Milo and Kees are each touched in their own way by an old, sick man who has no one.

Luna's father Simon reports to the ER with a large cut. Kyra discovers his secret. While Luna and Casper insist on psychological help, Rose suffers from shame.

Luna's friend has an epileptic seizure the morning after a party and Luna goes to the emergency room, broke and in good shape. She takes a bad turn with Kyra and her mother.

Luna wants to prove herself and assists in the operating room, much to Kyra's annoyance. She has to deal with a bully of a surgeon. Kees treats a Bulgarian man who has been thrown out of a car in front of the door.

Football riots cause chaos in the ER, while Milo is not feeling well at all. He treats an injured supporter who was going to donate his kidney to his wife, but the question is whether the transplant can still go ahead. Homeless diabetic Nico gives Kees the idea of ​​dating, but has to deal with a major loss himself. Kyra lashes out at a drunk, aggressive supporter. Luna misses a signal, with major consequences for the patient.

After her mistake, Luna struggles with fear of failure. She has to treat a wayward woman with a high BMI on her own, because Milo is rebellious and is mainly concerned with the results of his scan. Kyra enlists Casper's help with a patient who claims to have been poisoned. While Kees has a match with a nice woman, Rose feels lonely and tries to get closer to Casper. Olivia gets into trouble with Pierre.

Casper has to go to a conference in Berlin and tries to get Rose to come along. Rose has doubts and meanwhile gets Pierre on her roof, who wants her to fire Olivia. Luna, together with Casper, treats a confused man suspected of domestic violence. She discovers something she would rather not have known. Kees moves his rebellious mother to a nursing home and feels guilty, especially when it turns out that she has run away. Finally, Milo can no longer hide his illness.