Pablo considers himself lucky for having a happy home with two loving parents, Benjamin and Rita. All is well until Simon, a stranger who has nowhere to go, comes and finds shelter in their home. With Simon living with them, Pablo starts to notice strange things happening in their home, including Rita treating her husband critically. One night, Benjamin is found dead, and through a Manobo ritual, they find out that Simon is behind Benjamin's death. They soon discover cult items in Simon's belongings that Pablo's relatives say Simon used to put Rita under a love spell.

Leni Robredo was hesitant to enter politics at first. Dimples, as Leni, said that she was scared and that she wanted to be able to spend more time with her family.

Yolly is a mother who will do anything and everything for her children, four of whom have disorders. Yolly and her husband dream of having children of their own and build a family. Unfortunately, their genes are incompatible. Their firstborn has Down syndrome, while their second and third babies suffer from cerebral palsy. Despite the misfortune that has befallen their children, the couple loves them like they are normal children, like their fourth child who turns out to be the only one without physical and or mental disability. When Nick leaves to work overseas, Yolly is left with the responsibility of taking care of the children. While Yolly has accepted the fact that she is the mother of four disabled children, she isn't able to embrace the successive deaths of her two children. This is the fact that has made her despondent while holding on to her two other children, one of which also has disability.

Due to poverty, Juan did not get the opportunity to finish his schooling and promised himself that when the time comes, he will do everything to give his own children a proper education. But raising a family proved to be difficult for him and wife Melissa. Despite Juan working two jobs, making ends meet was impossible for the couple, forcing Melissa to look for work and ended up working far away from their kids. After some time, Juan does not hear from Melissa anymore and later finds out that she has been seeing someone else. Making matters worse, a storm devastates Juan's home, leaving him with the difficult decision to live in a cave. His kids are forced to walk four kilometers a day to go to school and have to endure insults from their classmates for their living environment.

Caitie is the first daughter of married couple Tine and Jayjay. The couple met when both were rebuilding their lives from failed relationships and suddenly found themselves in each other's arms. Seeing each other as life partners, they planned to get married and to have children. To the couple, the birth of Caitie made their union perfect and as it stood were both very happy on the day they first laid eyes on Caitie. When Caitie was three years old, symptoms of a mystery illness began surfacing such as rashes all over her body. In a span of three months, Caitie had to be confined in three different hospitals as doctors could not seem to diagnose her condition. Jayjay felt responsible for Caitie's condition due to his family's medical history, while Tine felt so lost that she already thought of ending their marriage. Consumed by hopelessness, they shared Caitie's story online to find support. An overwhelming response came their way and Caitie came to be known as Courageous Caitie.

June and Jess are the perfect example of identical twins as they not only look like each other but also act the same way. Sporting the same hairstyle, sharing the same taste in fashion, and using the same personal items, there isn't anything that can tell them apart. The two sisters share a strong relationship but had no idea that it will be put to the test once they enter college. Jess meets Luis and eventually falls in love with him. June had her doubts about Luis at first but as time passed Luis became close to her as well. In an unexpected turn of events, Luis suddenly confesses his true love for June and his plans to leave Jess to be with her instead.

Ilong has been taking care of his grandson Gilbert ever since he was just eight months old after his mother Elang left him to look for work in the city. Unfortunately, Elang fails to return to her firstborn after getting pregnant by another man. Since then, Ilong has worked so hard to provide for Gilbert, whose effeminate behavior he persistently shrugs off. Scared that his grandfather might not approve of his sexuality, Gilbert hides it from him and only openly expresses himself in school. Gilbert is about to enter college when Ilong starts losing jobs due to his old age and fails to provide for his grandson's education.

Since childhood, Bong already knows that he likes boys but does not have the courage to come out to his father, Fernando . So when his father died, Bong decides to let his real self shine through, which his mother, Lolet, fully accepts. Years later, Bong meets Nick and eventually becomes his boyfriend. Even when Bong decides to go to Madrid to fulfill his dream for his family, Nick remains committed to him. Until one day, Bong finds out that Nick is already married to a woman.

Victor desires a happy and simple life for his family. A determined and religious provider, he puts up a small bakery in Iba, Zambales with his wife, Marites. Seeing Victor provide the needs and wants of their family, Marites draws strength from his husband. Soon, Victor comes across and helps a homeless old lady, Aling Maring with her drug addict son Benwho seek food and shelter from him. He accepts them like family, but conflict arises in their household when the two suddenly take his entire income and ran away. Feeling betrayed, Victor suffers from depression and later turns his attention to gambling, distressing Marites and their children. The tables completely turn when Victor starts to become inscrutable as he experiences delusions and hallucinations – from being unexpectedly violent to his eldest son Carlo, to digging corpses, and burying saint figurines on spur of moment.

Lorena and her husband Norberto have always strived to build a prosperous family for their children. Through hard work, they were able to put up a successful chicharon, balut, and peanut business. Life seems to be going so well for their family until super typhoon Yolanda hit them. The devastating tragedy separated Lorena, Norberto, and their children from each other.