Milo does not want to admit that he has MS, but a patient with a failed cosmetic operation confronts him with his fate. Luna is looking for a resident position but unexpectedly faces Kyra. After his mother's accident, Kees throws himself into his work and into colleague Willeke from the children's department. Casper is disappointed in Rose and pleads with the new charming director Marleen for more psychiatric care in the ER.

Luna and Kyra compete for the position of doctor in training to become a specialist. Ingrid is concerned about a patient who is struggling with unexplained abdominal pain. Milo finds himself in a precarious situation and can no longer hide his illness from Luna. Casper makes Olivia think about her place in the Emergency Department. After a confrontation between Casper and Rose, Rose makes a decision about her marriage.

A power outage turns everything upside down and draws the attention of a diligent journalist. After unsuccessful resuscitation, Kees' emotions about his mother's death flare up and Milo tries to rekindle his friendship with Ingrid. Casper gives Olivia the chance to move up and Rose forces Marleen to be honest about what she is doing in the MCW. Luna treats a child with a strange bite wound and realizes that Kyra no longer wants to be in the operating room, but why?

Rose believes that the staff should know what is going on, but Marleen thinks differently. Luna and Kyra treat accident victims and Luna learns more about Kyra. Ingrid meets an old acquaintance on the treatment table and is the only one who sees that there is more going on. When Milo dismisses an incident as unimportant, she can no longer keep her mouth shut. Kees throws himself (a little too) enthusiastically at Willeke and Rose and Casper find each other again.