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In the Season 2 premiere, Spider-Man faces a new enemy named Mysterio. Meanwhile, Peter continues his search for Eddie.
Spider-Man faces off against Kraven the Hunter while Peter must decide between Liz Allen and Gwen Stacy.
Mysterio and Kraven join the ranks of the Sinister Six (including Sandman, Rhino, Vulture and Electro) in an attempt to capture Spider-Man once and for all.
As Peter Parker rings in the New Year, Spider-Man's newest villain, The Master Planner, plans to take over the world.
Things seem to be going well for Peter Parker when he is invited to Flash Thompson's birthday party. Things change, however, when Sandman returns with a score to settle.
When aliens infect John Jameson with toxic spores, he begins to increase in size and strength. Seeing this as a perfect opportunity to capture Spider-Man, J. Jonah Jameson manipulates his son into becoming a super-hero.
When Venom reveals Spider-Man's secret identity to the world, Peter Parker's family and friends are put in jeopardy.
Doctor Octopus, Hammerhead and Silver Sable fight over control of New York City's crime underworld.
Spider-Man encounters a group of super-villains, the New Enforcers, forcing him to battle Shocker, Ricohet and Ox. Meanwhile, Peter Parker's life isn't going much better.
In order to become the new Big Man, Hammerhead betrays Tombstone, Doctor Octopus and Silvermane. Now, an all out gang war has erupted in New York City, and it's up to Spider-Man to stop it.
Green Goblin returns and black-mails Liz Allen's brother, Mark. Spider-Man tries his best to stop him, but is it too late?
A new security cell at Ryker's, codenamed the Vault, opens and Spider-Man offers to be the first test subject. Unfortunately, Green Goblin traps him inside with several villains that he helped put away.
Both Peter Parker and Spider-Man make big decisions: Peter decides to break up with Liz and Spider-Man unmasks the Green Goblin. Unfortunately, nothing goes as planned.
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