Jirayu Tangsrisuk was born in Phichit, Thailand. He is the youngest child of Sermchai Tangsrisuk and Shotika Tangsrisuk. He has one older sister, Dr. Jularat Tangsrisuk, MD. His parents nicknamed him "James" after James Bond (from the James Bond films). After having finished junior high school from Wachira Kindergarten, Jirayu attended high school at Phichit Phitthakhom School, and at the same time he also was a territorial defense student. He completed Grade 3, which means he is equivalent and may request permission to use the title Staff Sergeant (completed Grade 3 combined with an academic degree), also he is exempt from conscription. After he'd finished high school, he then continued his education at the Faculty of Communication Arts at Rangsit University, in the field of radio and television broadcasting. Later in 2013 he received a scholarship (The Artist), therefore switched to study at the Faculty of Business Administration, majoring in Retail Business Management until graduation. He attended the graduation ceremony in December 2017.