Tiny Toon Adventures
Starting from Scratch (1x11)
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This episode is a homage to Don Bluth's An American Tail, only it's done with fleas instead of mice.
A family of fleas becomes separated when their younger child lands on Furrball. Buster, Babs and Plucky shrink themselves to flea size to help the young flea reunite with his family, who then take residence on Furrball.