Trinity Blood

The Crown of Thorns I: City in the Mist (1x23)

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Cain, having killed his brother, Abel, plots with Kampher to destroy the people of Rome and, soon after, the world. Sister Esther mourns beside a grave of Abel, when there's an attack on Albion. Virgil tells Esther that she's the Star of Hope, the one who is to lead Albion and the world to peace.