Rurouni Kenshin
A Wish Unrequited: Kenshin Departs (2x4)
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As the deadline for Kenshin's decision on whether to go to Kyoto nears Kaoru becomes anxious at the possibility of his leaving. After Okubo's assassination by Seta Sojiro, Kenshin decides to go to Kyoto and bids an emotional goodbye to Kaoru, implying that it is likely they will never meet again.