In commemoration of the 60th anniversary of President John F. Kennedy's assassination, Who Killed JFK? explores the pressing questions that still surround one of the most tragic moments of the 20th century. Award-winning journalist Soledad O'Brien and beloved filmmaker Rob Reiner team up to discover the truth behind the assassination, revealing how the ramifications of the 1963 tragedy still impact American society today.

Who wanted the president dead? And is the unexpected murder of the lead suspect the first clue in the answer to this mystery? Our hosts, Rob Reiner and Soledad O’Brien, discuss why the question “Who Killed JFK?” endures in the American imagination 60 years later. Did President Kennedy have a target on his back when he transformed from ‘Cold Warrior’ to global peacemaker?

Was there a coverup? The Warren Commission published a report in 1964 that claimed Lee Harvey Oswald was the sole gunman. But over a decade later, the House Select Committee on Assassinations claimed that President Kennedy was killed as the result of a ‘conspiracy.’ Why the conflicting results? With revelations over the last 60 years, flaws in both investigations are exposed.

What does the forensic evidence reveal? We start at the scene of the crime, move to the hospital and end with the strange autopsy. And with breaking news from one of Kennedy’s Secret Service Agents, the Single Bullet Theory will finally be put to rest. A big thank you to The 6th Floor Museum at Dealey Plaza and WFAA TV Collection.