Doraemon (1979)

Mind Changing Broth (16x6)

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When Gian and Suneo use Nobita as a scapegoat after breaking the glass of an angry swordsman, Doraemon gives Nobita the mind changing broth to change the swordsman's mind and make him get angry at Gian and Suneo instead. However, Shizuka gets exposed to the broth's affects as well which causes her to hate Nobita, much to his grief.