Road Runner and Wile E. Coyote

Hopalong Casualty (1x18)

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Wile E. Coyote tries to catch the Road Runner using a dynamite stick on a fishing pole, a Christmas present wrapping machine, and ACME Earthquake pills, which the Coyote discovers don't affect Road Runners, but only after he himself has angrily downed a whole bottle of the pills! The Coyote quakes and shivers away boulders and whole mountains before the pills wear off.