The doctors of Chastain are surrounded by new rules and doctors, as Red Rock Mountain Medical takes over the hospital. Conrad finds himself in a dangerous situation when the construction for a new neurosurgery center causes a gas explosion at Chastain. New hotshot neurosurgeon, Barrett Cain, is put to the test with a complicated surgery. Mina acts as a support for Nic, who is struggling with a devastating loss.

Cain tries to recruit Bell and Kit to join him on a dangerous surgery, with the intent of garnering publicity for the hospital. The Raptor finds himself with an emotional attachment to a patient whose life is put in his hands. A friend of Mina arrives at the hospital with shocking news. Devon rotates out of the ER. Nic plans a surprise for Conrad.

When a police officer shows up to the ER with an injured criminal that he caught in the act, it's up to the Chastain staff to keep him alive in order to save an innocent life. Nic gets roped into a surgical rotation with Cain that leaves her questioning the way he operates, and Conrad makes a shocking discovery about the hospital. Meanwhile, Bell pursues a new fiscal venture that may bring him into a whole new market.