Katie Piper meets people who have been avoiding their health troubles and hiding from the doctor and dentist for years. They include Leicestershire couple Janice and Greg, who have serious dental issues, while in Scotland, Joanne is stuck in a never-ending cycle with her psoriasis. Will she give up her current life with friends and family to try something new?

Katie Piper meets a woman who uses moulded chewing gum to disguise her damaged front teeth, a marathon runner who is unaware of the effect his varicose veins could have on his health, and a young woman struck by a condition that has paralysed the side of her face. Plus, a man in Wales discovers an unlikely treatment that may offer a life-changing cure for a birthmark on his face.

In Folkestone, 21-year-old Ben decides he wants to try to turn things around after years of dental neglect. Meanwhile, in Dartford, Matt wants to get to grips with a lifelong condition that no amount of exercise has been able to solve; gynecomastia, or manboobs. Cameras also follow Hayley, who was struck by a severe case of acne during her first pregnancy, and Derek, who is undergoing a new procedure to help him lose weight. Plus, Nicky receives a 'bionic arm', the most advanced prosthetic limb in the country.