In the first of two parts, American genealogist Tony Burrows consults biblical historians and archaeologists to identify factual evidence suggesting the existence Jesus' half and full-blood siblings. Join Burrows as he travels from ancient sites in Judea to forensic labs in Europe to dissect the clues revealing an alternate perspective on Jesus' family.

The second part of the special examines the practical and moral backing of a family that extended beyond Jesus' parents to his grandfather Joachim; his cousin John the Baptist; his "brothers" Simon, Jude, Joses and James; his uncle Clophas and his aunt Mary; his "nephew" Simon and his "great nephews" Zoker and James.