Fran and Sal meet some of the top pizza masters across the country, as they travel to Portland, Oregon to devour some house-smoked bacon pizza at Apizza Scholls. And after grabbing wild nettles and sausage slices in Oakland, California, Sal and Fran head back to New York City to make their own Burrata cheese for an authentic pizza pie.

Sal and Fran discover unique dough recipes and techniques across the country. The guys start by making 'no-knead' dough in New York City - at Company, then try their hands at a sourdough pizza crust in Northern California, and ending their trip with a one-of-a-kind cornmeal deep-dish crust from Dove Vivi in Oregon.

Fran and Sal explore some of America's most legendary neighborhood pizzerias, starting with a venture to Connecticut pizzeria Colony Grill owned by four childhood friends. In Michigan, Sal and Fran receive a lesson on the origins of the 'Detroit Sicilian' as they visit Buddy's, and celebrate a 100-year anniversary in New Jersey, home of the oldest, continuously run pizzeria in the country.

Fran and Sal visit some of the most successful women in pizza. Starting with a tasty Spicy Jerk Chicken Pizza at Amici's Pizza in Michigan run by Jennifer Stark and Maureen McNamara. Then in Portland, Oregon, the Minnick sisters share their Salted Cod Pizza from Lovely's Fifty Fifty with Sal and Fran. And the cousins head to Philadelphia, where two mini-moguls, Valerie Safran and Marcie Turner, share a taste of their Guanciale and Truffled Farm Egg Pizza that has helped them take over an entire city block.

The cousins seek out the experimental & unconventional, as Sal and Fran enjoy Indian Tandoori Chicken Pizza at Zante in San Francisco. And if a delectable wood-fired Truffle Oil Pizza from a tiny food cart in Oregon doesn't sound appealing enough, Fran and Sal get their taste buds on a Smoked Brisket, followed by an Ice Cream topped slice, in a wacky pizza museum in Philadelphia.

Sal and Fran find some deliciously different pizza toppings, even getting wet and dirty for some of the ingredients. Whether it's trying deep-fried slices at Forcella in Brooklyn, a simply distinctive focaccia pie at Liguria Bakery in San Francisco, or clam farming in Larkspur for a fresh clams and Sopressata combination, Fran and Sal will have their hands full with these mouthwatering toppings.