Assala was born in Damascus, Syria to a middle class couple. Mostafa Nasri, Assala's father, was a revered composer and singer. Assala began her musical career by performing patriotic, religious, and children's songs when she was four years old. She sang the theme song "Qessas Al Sho'oub", of the cartoon show, Hekayat Alamiyah. In 1984, Mostafa Nasri died after suffering from internal bleeding caused by a car accident. Aged 15 she helped to take care of her siblings Aman, Ayham, Reem and Anas with her mother Aziza Al-Babelli.
Assala's commercial musical career debuted in 1991 with the Egyptian song hit Law Ta'rafou. The album had 4 Egyptian songs in the oriental operatic Classic Egyptian tarab style. The album was an instant hit in Egypt back at that time with heartbreaking songs like "Ya Sabra Yana" and "Samehtak Ketir".She quickly strengthened her presence in the Arab world and became one of the most important female artists in the Middle East.