Celebrity roasters Cedric the Entertainer, Margaret Cho, Kathy Griffin, Lil Rel Howery, Lisa Lampanelli, Natasha Leggero, Chris Redd and Iliza Schlesinger play Celebrity Weakest Link, where at the end of each trivia round, the contestants vote out who they perceive to be the weakest link, and Lynch sends them packing.

Jane Lynch hosts celebrity television mothers Melinda Clarke (The O.C.), Jackée Harry (Sister, Sister), Mary-Margaret Humes (Dawson's Creek), Constance Marie (George Lopez), Monica Potter (Parenthood), Caroline Rhea (Sabrina the Teenage Witch), Sherri Saum (The Fosters), and Bellamy Young (Promised Land). At the end of each trivia round, the contestants vote out who they perceive to be the weakest link, and Lynch sends them packing.

Jane Lynch hosts celebrity guests Joel Kim Booster, Laverne Cox, Ron Funches, Carson Kressley, Jon Lovitz, Cheri Oteri, Adam Pally and Andy Richter. At the end of each trivia round, the contestants vote out who they perceive to be the weakest link, and Lynch sends them packing.

Jane Lynch hosts a group of celebrity pairs who acted together as teenagers, including Tatyana Ali, Shenae Grimes, Matt Lanter, Beverly Mitchell, Scott Porter, Daphne Reid, Aimeé Teegarden, and Barry Watson. At the end of each trivia round, the contestants vote out who they perceive to be the weakest link, and Lynch sends them packing.

Jane Lynch hosts celebrity guests Cynthia Bailey, Tamar Braxton, Kate Gosselin, Vicki Gunvalson, Dorinda Medley, Shanna Moakler, Kendra Wilkinson, and Jill Zarin. At the end of each trivia round, the contestants vote out who they perceive to be the weakest link, and Lynch sends them packing.

Jane Lynch hosts groups of reality couples Kelsey Anderson, Melissa Gorga, Joe Gorga, Joe Graziadei, Lauren Speed-Hamilton, Cameron Hamilton, Heidi Montag, and Spencer Pratt. At the end of each trivia round, the contestants vote out who they perceive to be the weakest link, and Lynch sends them packing.

Jane Lynch hosts various celebrity competitors on the FOX competition 'Special Forces: World's Toughest Test', including Tyler Cameron, Gus Kenworthy, Kenya Moore, Jack Osbourne, Kyla Pratt, Jovon Quarles, Rudy Reyes, and Christy Carlson Romano. At the end of each trivia round, the contestants vote out who they perceive to be the weakest link, and Lynch sends them packing.

Jane Lynch hosts a group of actors who played doctors on television, including Torrey Devitto (Chicago Med), Dr. Dubrow (Botched), Ryan Eggold (New Amsterdam), Jason George (Grey's Anatomy), Hill Harper (The Good Doctor), Dr. Will Kirby (Dr. 90210), Dr. Sandra Lee (Dr. Pimple Popper), and Kal Penn (House). At the end of each trivia round, the contestants vote out who they perceive to be the weakest link, and Lynch sends them packing.

Jane Lynch hosts celebrity contestants Jonathan Bennett, Rachel Leigh Cook, Taye Diggs, Vivica A. Fox, Melissa Joan Hart, Eric Lloyd, Luke Macfarlane, and Reginald VelJohnson. At the end of each trivia round, the contestants vote out who they perceive to be the weakest link, and Lynch sends them packing.

Jane Lynch hosts celebrity football legends Emmanuel Acho, Vernon Davis, Keyshawn Johnson, James Jones, Cam Jordan, LeSean McCoy, Sony Michel, and Andrew Whitworth. At the end of each trivia round, the contestants vote out who they perceive to be the weakest link, and Lynch sends them packing.