While working undercover for the Street Fighter operation, Guile gets contacted by Escher. Bison had just stolen a biological virus that can kill in 24 hours that he stole from Guile's old flame, Lucinda (or "Cindy"). Guile assembles a team consisting of Chun-Li, Ryu, Ken and Blanka, and heads to the jungle to put an end to Bison's schemes. Unfortunately both Ryu and Blanka contract the virus.
